If your dog struggles with constant itching, skin inflammation, or allergy flare-ups, there’s a good chance your veterinarian has mentioned Apoquel. While Apoquel can be effective, it’s not always the right fit for every dog. Side effects, long-term safety concerns, cost, or pre-existing health conditions often lead pet parents to ask an important question: what can I give my dog instead of Apoquel?
The good news is that there are several Apoquel alternatives for dogs, including prescription medications, over-the-counter (OTC) products, and natural remedies. In this guide, we’ll explain how Apoquel works, why some owners seek an alternative to Apoquel, and explore the best natural, prescription, and non-prescription Apoquel substitutes for dogs—so you can make a more informed decision with your vet.
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What Is Apoquel and Why Is It Prescribed for Dogs?
Apoquel (oclacitinib) is a prescription medication commonly used to treat allergic itching (pruritus) and inflammation in dogs. It works by targeting Janus kinase (JAK) enzymes, which play a role in the immune signals that cause itching and redness.
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What Apoquel Is Commonly Used For
- Environmental allergies (pollen, dust mites, mold)
- Food-related allergic reactions
- Chronic skin itching and inflammation
- Atopic dermatitis
One reason Apoquel is popular is that it often works quickly—sometimes within hours. However, speed isn’t everything, especially when long-term health is involved.
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Why Pet Owners Look for Apoquel Alternatives
Despite its effectiveness, Apoquel isn’t suitable for every dog. Many pet parents actively search for apoquel alternatives due to the following concerns:
Potential Side Effects
Some dogs experience:
- Vomiting or diarrhea
- Lethargy
- Increased susceptibility to infections
- Skin growths or lumps with long-term use
Long-Term Immune Suppression
Because Apoquel affects immune pathways, long-term use may suppress immune function. This is why it’s generally not recommended for puppies under 12 months or dogs with cancer.
Cost Considerations
Apoquel can be expensive, especially for large dogs requiring daily dosing. This pushes many owners to seek a more affordable replacement for Apoquel.
Not Effective for Every Dog
Some dogs simply don’t respond well to Apoquel, leading owners to ask: what is a good substitute for Apoquel for dogs?
Prescription Apoquel Alternatives for Dogs
If you’re looking for a prescription Apoquel alternative, several vet-approved medications may help control itching and allergies.
1. Cytopoint (Lokivetmab)
Cytopoint is one of the most popular apoquel alternatives for dogs. It’s an injectable monoclonal antibody that targets a specific itch-causing protein (IL-31).
Pros:
- Works for 4–8 weeks per injection
- Minimal systemic side effects
- Safe for many dogs who can’t take Apoquel
Cons:
- Requires vet visits
- May be costly over time
For dogs with chronic allergies, Cytopoint is often considered a strong apoquel substitute for dogs.
2. Steroids (Prednisone, Prednisolone)
Steroids have long been used to treat inflammation and itching.
Pros:
- Fast-acting
- Inexpensive
- Effective for severe flare-ups
Cons:
- Significant side effects with long-term use
- Increased thirst, appetite, and urination
- Potential liver and immune issues
Steroids may work as a short-term alternative to Apoquel, but they are generally not ideal for chronic management.
3. Cyclosporine (Atopica)
Cyclosporine suppresses immune activity related to allergies and is sometimes used as an apoquel for dogs alternative.
Pros:
- Suitable for long-term allergy control
- Useful when Apoquel fails
Cons:
- Slow onset (weeks)
- Digestive side effects
- Higher cost
Non-Prescription Apoquel for Dogs: OTC Options
If you’re searching for a non prescription Apoquel for dogs, OTC products can help manage mild to moderate symptoms, especially when combined with dietary and lifestyle changes.
1. Antihistamines (Vet-Approved)
Common options include:
- Diphenhydramine (Benadryl)
- Cetirizine (Zyrtec)
- Loratadine (Claritin)
Pros:
- Affordable
- Easy to find
- Mild side-effect profile
Cons:
- Limited effectiveness for severe allergies
- Dosage must be vet-approved
While not a full substitute for Apoquel for dogs, antihistamines may help reduce itch intensity.
2. Medicated Shampoos & Topicals
Shampoos containing:
- Oatmeal
- Chlorhexidine
- Ketoconazole
- Aloe vera
These products soothe inflamed skin and reduce secondary infections.
Best for:
- Localized itching
- Dogs with skin infections alongside allergies
3. Omega-3 Fatty Acid Supplements
Fish oil and krill oil supplements support skin health and reduce inflammation naturally.
Benefits:
- Improves coat condition
- Supports immune balance
- Often used as a replacement for Apoquel in mild cases
Natural Alternatives to Apoquel for Dogs
Many pet owners prefer a natural alternative to Apoquel for dogs, especially for long-term management or mild to moderate allergies.
1. CBD Oil for Dogs
Because of its relaxing and anti-inflammatory qualities, CBD is becoming more and more well-liked as a natural alternative to Apoquel.
Potential Benefits:
- Reduces itching and inflammation
- Supports immune balance
- Helps with anxiety linked to constant discomfort
CBD is not a cure, but it can be part of a holistic apoquel alternative strategy when sourced from pet-specific, third-party-tested products.
2. Quercetin (Nature’s Antihistamine)
Quercetin is a plant-based flavonoid often called a natural antihistamine.
Why it helps:
- Reduces histamine release
- Supports immune modulation
- Often combined with bromelain for better absorption
For many dogs, quercetin serves as a gentle substitute for Apoquel.
3. Herbal Remedies
Certain herbs may help manage allergy symptoms:
- Licorice root (anti-inflammatory)
- Nettle leaf (antihistamine properties)
- Turmeric (curcumin reduces inflammation)
These should be used under veterinary guidance, especially when combined with other treatments.
4. Probiotics and Gut Health Support
Allergies often start in the gut. Probiotics may:
- Improve immune response
- Reduce inflammatory reactions
- Support overall digestive health
A healthy gut can reduce the need for stronger medications and act as a long-term apoquel alternative.
Diet Changes as an Apoquel Replacement Strategy
Food allergies are a major cause of itching. Before committing to medication, dietary changes may help answer the question: what can I give my dog instead of Apoquel?
Common Food Triggers
- Chicken
- Beef
- Dairy
- Wheat
- Corn
Helpful Diet Approaches
- Limited-ingredient diets
- Novel protein diets (duck, venison, rabbit)
- Grain-free (when vet-approved)
For some dogs, removing the allergen eliminates the need for any apoquel substitute for dogs.
Comparing Apoquel Alternatives: What Works Best?
| Apoquel | Fast | Severe itching | Yes |
| Cytopoint | Moderate | Chronic allergies | Yes |
| Steroids | Very fast | Acute flare-ups | Yes |
| Antihistamines | Mild | Seasonal allergies | No |
| CBD | Gradual | Inflammation & itch | No |
| Omega-3s | Slow | Skin support | No |
| Diet Change | Gradual | Food allergies | No |
There is no one-size-fits-all alternative to Apoquel. The best solution often combines multiple approaches.
How to Choose the Right Apoquel Alternative for Your Dog
When selecting from various apoquel alternatives for dogs, consider:
- Severity and cause of allergies
- Dog’s age and health history
- Long-term safety
- Budget
- Vet recommendations
Many dogs do best with a layered approach—such as a natural anti-inflammatory, dietary changes, and occasional prescription support.
When You Should Talk to a Veterinarian
Even if you’re exploring a non prescription Apoquel for dogs, veterinary guidance is essential if:
- Itching is severe or worsening
- There are open sores or infections
- Your dog exhibits signs of discomfort or sluggishness
- Natural remedies aren’t helping
A vet can help you identify the safest and most effective replacement for Apoquel tailored to your dog.
Final Thoughts
Apoquel can be effective, but it’s not the only solution. Whether you’re looking for natural alternatives to Apoquel, a prescription apoquel substitute for dogs, or a non prescription Apoquel for dogs, there are many options worth exploring.
The secret is to recognize the unique requirements of your dog and working with your veterinarian to find the safest, most sustainable plan. With the right combination of treatments, many dogs find lasting relief—without relying solely on Apoquel.
FAQs
What is a good substitute for Apoquel for dogs?
Cytopoint is a popular prescription option, while CBD, omega-3 supplements, and quercetin are commonly used natural substitutes depending on severity.
What can I give my dog instead of Apoquel?
Options include Cytopoint, antihistamines, CBD oil, dietary changes, probiotics, and herbal remedies—based on your dog’s condition.
Is there a non-prescription Apoquel for dogs?
There is no exact OTC equivalent, but antihistamines, CBD, omega-3s, and medicated shampoos may help manage symptoms.
Are natural alternatives to Apoquel safe?
Many natural options are safe when properly dosed and vet-approved, especially for long-term use.
Can I stop Apoquel suddenly?
Never stop prescription medication without consulting your veterinarian, especially if your dog has been on Apoquel long-term.